Recent Advance in Clotting Factor Concentrates
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چکیده
منابع مشابه
Activated clotting factors in factor IX concentrates.
The precise quantitation of activated factors in human factor IX concentrates has been accomplished with the use of recently developed, specific assays for factors IXa, Xa, and thrombin. The assay for factor IXa, which measures the initial rate of 3H-factor-X activation, was shown to be specific for factor IXa in the concentrates. Activated factor IX concentrates contained 1.0-2.3 microgram/ml ...
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Clotting factor concentrates (CFCs) underwent tremendous modifications during the last forty years. Plasma-derived concentrates made the replacement therapy feasible not only in the hospital but also at patients' home by on-demand or prophylactic regimen. Virucidal methods, implemented soon after hepatitis and AIDS outbreak, and purification by Mabs made the plasma-derived concentrates safer an...
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TRANSFUSION1993—Vol. 33, No, 5FACTOR CONCENTRATES 1992433 12. Finlayson JS, Tankersley DL, Anti-HCV screening and plasmafractionation: the ease against (letter). Lancct 1990;335:1274-5.13. Pneumocystis carina pneumonia among persons with hemophiliaA . MMWR Morb Mortal Wkly Rep 1982;31:365-7.14. Krciss JK, Kitchen LW, Princc HE, Kasper CK, Essex M . Antibody to h...
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Factor VIII is an important glycoprotein involved in hemostasis. Insertion of expression vectors containing either the full-length cDNA sequence of human factor VIII (FLrFVIII) or B-domain deleted (BDDrFVIII) into mammalian cell lines results in the production of recombinant factor VIII (rFVIII) for therapeutic usage. Three commercially available rFVIII concentrates (Advate, Helixate NexGen and...
متن کاملHepatitis C viral RNA in clotting factor concentrates and the development of hepatitis in recipients.
The polymerase chain reaction (PCR) was used to detect hepatitis C (HCV) viral sequences (HCV-RNA) in clotting factor concentrates that had been stored at 4 degrees C for 1 to 16 years. A total of 43 concentrates were tested, comprising 31 batches of factor VIII, 6 of factor IX, 2 of antithrombin III, 3 of FEIBA, and 1 of factor VII. HCV-RNA was detected in 13 of the 43 batches (30.2%). Concent...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1995
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.6.433